It's actually Wynn Resorts' (WYNN 0.19%) namesake Wynn Las Vegas on the far north end of The Strip that earns the most money of any casino. In gaming, when measuring cash flow we look at EBITDA, or earnings before interest, taxes, depreciation, and amortization.
Realizing that gambling would be profitable for local business, the Nevada state legislature legalized gambling at the local level in 1931. Las Vegas, with a small but already well-established illegal gambling industry, was poised to begin its rise as the gaming capital of the world.