As a general guideline, side bets in blackjack have high house edges and should be avoided. But if you insist on trying your luck, at least stick to the side bets that have the lowest house edge. Better yet, learn a counting system that is specific to the side bet and that can give you an edge.
Side bets can be entertaining and potentially offer higher payouts than the main blackjack game. However, they also have a higher house edge, which means they are riskier in the long run.