Bet365 Sportsbook is available only in Colorado, New Jersey, Louisiana, Ohio, Virginia, Iowa, and Kentucky. Therefore, the popular betting site is not yet legal in the other 43 U.S. states.
However, winning too often will see your account with bet365 restricted. This is why bookmakers don't like professional gamblers who consistently win. It is bad for business, and bookmakers are out to make money, not lose them.