Yes, you can certainly win real money while playing slots online. Every time you use actual money to bet on the games, you will also receive real winnings. Moreover, you can even win money by playing online slots with bonuses and extra spins awarded by the casino.
It is an irrefutable fact that people win jackpots at online slots unless, of course, you go to a rogue casino. As long as the online casino you choose has a good reputation, you are guaranteed to win real money.